Synaptic properties
This sub-section evaluates the anatomy and physiology of in silico excitatory and inhibitory synaptic pathways in the reconstructed microcircuit against relevant literature.
Evaluated properties include spine and bouton densities, synaptic innervation patterns, mean. no. of synaptic contacts/connection, connection probabilities, transm itter release probabilities, AMPA, NMDA, GABAA, and GABAB receptor peak conductances, EPSC/IPSC kinetic and dynamic properties (latency, amplitude, rise time & decay time constant), EPSP/IPSP kinetic and dynamic properties (latency, amplitude, rise time & decay time constant), transmission failure rates, c.v. of EPSP/IPSP amplitudes, and short term depression & facilitation.
The results of the consistency check were categorized as consistent, inconsistent, possibly consistent, input,not implemented or not applicable based on agreement with a given evaluation criterion.
39 paper(s) | |
5 paper(s) | |
5 paper(s) | |
17 paper(s) | |
10 paper(s) |
consistent - Hellwig, B - A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- connection probability within 50 - 100 microns
- id
- 1
- species
- rat
- age
- 4-6 weeks old
- brain region
- V1
- layer
- 2 and 3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- connection probability
- key result(s)
- 0.5 to 0.8 connection probability for directly adjacent neurons 0.0-0.15 for those 500 um apart
- pmid
- 10664098
- title
- A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex.
- contact Name
- Hellwig, B
- contributed by
- Melissa
- checked by
- SR
- further action
- SR
consistent - Hellwig, B - A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- common neighbours in L2/3
- id
- 2
- species
- rat
- age
- 4-6 weeks old
- brain region
- V1
- layer
- 2 and 3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- connection points
- key result(s)
- 1-3 connections between adjacent cells
- pmid
- 10664098
- title
- A quantitative analysis of the local connectivity between pyramidal neurons in layers 2/3 of the rat visual cortex.
- contact Name
- Hellwig, B
- contributed by
- Melissa
- checked by
- SR
- further action
consistent - Maxim Volgushev - Adaptation at synaptic connections to layer 2/3 pyramidal cells in rat visual cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- the USE and D values reported are consistent with what we prescribe for connections between L23PCs
- id
- 3
- species
- rat
- age
- adult
- brain region
- visual
- layer
- 2,3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- dynamic properties
- key result(s)
- results suggest, that apart from decreasing the amplitude of postsynaptic responses, adaptation may produce synapse-specific effects, which could result in a kind of re-distribution of activity within neural networks.
- pmid
- 15758049
- title
- Adaptation at synaptic connections to layer 2/3 pyramidal cells in rat visual cortex.
- contact Name
- Maxim Volgushev
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Jones RS - Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors.
- input/validation/consistent
- consistent
- evaluation criterion
- sIPSC & sEPSC frequencies in L2/3 PCs in S1 are ballpark similar with L2PCs in entorhinal cortex
- id
- 4
- species
- rat
- age
- brain region
- entorhinal cortex
- layer
- 2,5
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- Background synaptic activity
- key result(s)
- Considerable evidence now points to a role of spontaneous background synaptic activity in control of neuronal, and hence network excitability
- pmid
- 15498804
- title
- Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors.
- contact Name
- Jones RS
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Huguenard, J - Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons.
- input/validation/consistent
- consistent
- evaluation criterion
- EPSP amplitude of L4SS/L4PC -> FS, L4SS/L4PC -> L4SS/L4PC, L4SS/L4PC -> RSNP (SOM+ve?)
- id
- 5
- species
- rat
- age
- adult
- brain region
- S1
- layer
- L4
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- Thamocortical responses
- key result(s)
- (1) the strength of unitary excitatory connections of spiny neurons is similar among different targets; (2) although inhibition from regular-spiking nonpyramidal interneurons to spiny neurons is comparable in strength to excitatory connections, inhibition mediated by fast-spiking (FS) interneurons is 10 times more powerful; (3) TC EPSPs elicit reliable and precisely timed action potentials in FS neurons; and (4) a small number of FS neurons mediate thalamocortical feedforward inhibition in each spiny neuron and can powerfully shunt TC-mediated excitation.
- pmid
- 16436609
- title
- Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons.
- contact Name
- Huguenard, J
- contributed by
- SR
- checked by
- SR
- further action
consistent - Hestrin, S - Burst firing induces a rebound of synaptic strength at unitary neocortical synapses.
- input/validation/consistent
- consistent
- evaluation criterion
- EPSC kinetics from L2/3 PCs to L2/3 FS cells
- id
- 6
- species
- rat
- age
- p14-p19
- brain region
- S1
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- IN, PC
- aspect
- Synaptic efficacy
- key result(s)
- In the presence of ongoing activity, neocortical synapses may functionally facilitate following burst firing
- pmid
- 10634900
- title
- Burst firing induces a rebound of synaptic strength at unitary neocortical synapses.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
consistent - Isaac, JTR - Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- GABAergic transmission in L4
- id
- 7
- species
- mouse
- age
- p3-p7
- brain region
- S1
- layer
- 4
- presynaptic cell
- IN
- postsynaptic cell
- SS
- aspect
- GABAergic transmission
- key result(s)
- GABAergic recruitment occurs at P6–7 as a result of coordinated increases in thalamic drive to fast-spiking interneurons, fast-spiking interneuron–stellate cell connectivity and hyperpolarization of the GABAA receptor–mediated response
- pmid
- 17351636
- title
- Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex.
- contact Name
- Isaac, JTR
- contributed by
- SR
- checked by
- SR
- further action
consistent - Alan Larkman - Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions.
- input/validation/consistent
- consistent
- evaluation criterion
- spine density and distribution
- id
- 8
- species
- rat
- age
- rat
- brain region
- rat
- layer
- L2/3 and L5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- spine length and distribution for L5TTPCs
- key result(s)
- Average spine density = 2/um2 used to correct area for spines
- pmid
- 1711059
- title
- Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions.
- contact Name
- Alan Larkman
- contributed by
- Etay Hay
- checked by
- SR
- further action
consistent - H. RUTH CLEMO - Dendritic spine density in multisensory versus primary sensory cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- spine density and distribution
- id
- 9
- species
- ferret
- age
- Young, adult (n 5 3; 132 days old; 1.4 kg weight)
- brain region
- S1 and other regions
- layer
- in layers 2-3 and layers 5-6 for each cortical area
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- dendritic spine density
- key result(s)
- Primary sensory regions A1 and S1 showed remarkably similar average spine densities (A1 = 1.27 spines/μm ± 0.3 s.d.; S1 = 1.14 spines/μm ± 0.3),
- pmid
- 22488884
- title
- Dendritic spine density in multisensory versus primary sensory cortex.
- contact Name
- H. RUTH CLEMO
- contributed by
- Mirjia Herzog
- checked by
- SR
- further action
consistent - Bacci, A - Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.
- input/validation/consistent
- consistent
- evaluation criterion
- sIPSC frequencies in L5TTPCs
- id
- 10
- species
- rat
- age
- p18-p25
- brain region
- S1
- layer
- 5
- presynaptic cell
- IN
- postsynaptic cell
- aspect
- Autaptic modulation
- key result(s)
- Asynchronous release decreases FS-cell spike reliability and reduces the ability of PCs to integrate incoming stimuli into precise firing.
- pmid
- 20927409
- title
- Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.
- contact Name
- Bacci, A
- contributed by
- SR
- checked by
- SR
- further action
consistent - Chris J. McBain - Differential synaptic processing separates stationary from transient inputs to the auditory cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- In mouse A1, the release probability and EPSC amplitudes of L2/3PC connections appear to be in the ballpark range for similar connections in rat S1
- id
- 11
- species
- mouse
- age
- p18-p28
- brain region
- auditory cortex
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- cortico-cortical projections / P
- key result(s)
- We recorded from over 100 pairs of layer II/III pyramidal neurons, which resulted in 37 synaptic connections in 35 pairs (two were reciprocally connected).
- pmid
- 11694887
- title
- Differential synaptic processing separates stationary from transient inputs to the auditory cortex.
- contact Name
- Chris J. McBain
- contributed by
- MR
- checked by
- SR
- further action
consistent - Ropert, N - Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses.
- input/validation/consistent
- consistent
- evaluation criterion
- GABAa receptor kinetics. IPSC conductance, rise and decay times.
- id
- 12
- species
- rat
- age
- p13-p18
- brain region
- V1
- layer
- 5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- Pharamacology
- key result(s)
- By comparing the facilitation induced by 1 μM zolpidem on outside-out patches and mIPSCs, we estimated the concentration of GABA seen by the postsynaptic GABAA receptors to be ∼300 μM after single vesicle release. We have estimated a similar degree of receptor occupancy at room and physiological temperature.
- pmid
- 9880578
- title
- Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses.
- contact Name
- Ropert, N
- contributed by
- SR
- checked by
- SR
- further action
consistent - Stuart, GJ - Excitatory actions of GABA in the cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- GABAa reversal potential reported is consistent with what we prescribe.
- id
- 13
- species
- rat
- age
- p20-p30
- brain region
- S1
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Excitatory effects of GABAa
- key result(s)
- The activation of either somatic or dendritic GABAA receptors produces depolarization from rest that can, depending on location and timing, facilitate action potential generation when paired with otherwise subthreshold excitatory inputs
- pmid
- 12546824
- title
- Excitatory actions of GABA in the cortex.
- contact Name
- Stuart, GJ
- contributed by
- SR
- checked by
- SR
- further action
consistent - Hestrin, S - Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- Frequency dependent depression of FS-PC and PC-FS connections in L5
- id
- 14
- species
- rat
- age
- p14-p17
- brain region
- S1
- layer
- 5
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- Excitatory-inhibitory balance
- key result(s)
- These results suggest that inhibitory terminals of fast-spiking cells are better equipped to support prolonged transmitter release at a high frequency compared with excitatory ones. This difference in frequency-dependent depression could produce a relative increase in the impact of inhibition during periods of high global activity and promote the stability of cortical circuits.
- pmid
- 10196566
- title
- Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
consistent - Mieko Morishima - Highly differentiated projection-specific cortical subnetworks.
- input/validation/consistent
- consistent
- evaluation criterion
- release probability, onset latency, unitary EPSC amplitudes, and C.V. of EPSC amplitude of L5PC connections in pFC are ballpark similar
- id
- 15
- species
- rat
- age
- p17-p21
- brain region
- frontal
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- intracortical connectivity of pyramidal neurons
- key result(s)
- the pyramidal projection system is segregated into different output channels according to subcortical target and thalamic input, and information flow within and between these channels is selectively organized
- pmid
- 21753015
- title
- Highly differentiated projection-specific cortical subnetworks.
- contact Name
- Mieko Morishima
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Gabor Tamas - Identified sources and targets of slow inhibition in the neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- IPSP amplitudes beween NGCs and PCs
- id
- 16
- species
- rat
- age
- P19-35
- brain region
- S1
- layer
- L2/3
- presynaptic cell
- NGC
- postsynaptic cell
- PC
- aspect
- GABA B kinetics and dynamics
- key result(s)
- neurogliaform cells combined GABA and GABA B receptor mediated responses with single action potentials and that predominantly targeted the dendritic spines of pyramidal neurons.
- pmid
- 12649485
- title
- Identified sources and targets of slow inhibition in the neocortex.
- contact Name
- Gabor Tamas
- contributed by
- Shruti
- checked by
- SR
- further action
consistent - Nicoll, A - Laminar origins of inhibitory synaptic inputs to pyramidal neurons of the rat neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- ballpark numbers for IPSP kinetic properties in L2/3 PCs. NB: contains additional useful data on cholinergic modulation of L23 PCs
- id
- 17
- species
- rat
- age
- p14-p16
- brain region
- S1
- layer
- L5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- IPSP kinetics
- key result(s)
- This study showed that pyramid cell-inhibitory neuron interconnections are extensive but their spatial organization varies with cell class and with cortical layer.
- pmid
- 8951715
- title
- Laminar origins of inhibitory synaptic inputs to pyramidal neurons of the rat neocortex.
- contact Name
- Nicoll, A
- contributed by
- SR
- checked by
- SR
- further action
consistent - Petersen, C - Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex
- input/validation/consistent
- consistent
- evaluation criterion
- EPSP amplitudes from PC -> SOM, PC -> BC; IPSP amplitudes from SOM -> PC, BC ->PC
- id
- 18
- species
- mouse
- age
- p17-22
- brain region
- somatosensory barrel cortex
- layer
- 2,3
- presynaptic cell
- PC, SOM, FS
- postsynaptic cell
- aspect
- Role of synaptic interactions between nearby excitatory and inhibitory neurons of the neocortex in sensory processing
- key result(s)
- FS GABAergic neurons play an important role in neocortical microcircuit function through their strong local synaptic connectivity
- pmid
- 22402650
- title
- Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex
- contact Name
- Petersen, C
- contributed by
- John Fielden
- checked by
- SR
- further action
consistent - Jones, KA - NMDA- and non-NMDA-receptor components of excitatory synaptic potentials recorded from cells in layer V of rat visual cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- Receptor numbers for TTL5 connections
- id
- 19
- species
- rat
- age
- P14-16
- brain region
- visual cx
- layer
- 2,3,5
- presynaptic cell
- cells in L2/3 or axons in white matter
- postsynaptic cell
- PC
- aspect
- NMDA effects on EPSP characteristics
- key result(s)
- Blocking NMDA (with APV) = small reduction in peak amplitude, significant reduction in the falling phase of EPSPs i.e reduced the size of the EPSP. Bathing in Mg2+ = amplitude of EPSP increases substantially
- pmid
- 2902203
- title
- NMDA- and non-NMDA-receptor components of excitatory synaptic potentials recorded from cells in layer V of rat visual cortex.
- contact Name
- Jones, KA
- contributed by
- Melissa
- checked by
- SR
- further action
consistent - Katharina Kaiser - Postsynaptic calcium influx at single synaptic contacts between pyramidal neurons and bitufted interneurons in layer 2/3 of rat neocortex is enhanced by backpropagating action potentials.
- input/validation/consistent
- consistent
- evaluation criterion
- the USE value reported is consistent with the prescribed value for PC-BTC connections in the reconstructed microcircuit
- id
- 20
- species
- rat
- age
- p13 - p15
- brain region
- somatosensory cortex
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- bitufted
- aspect
- short-term plasticity
- key result(s)
- Postsynaptic calcium influx at single synaptic contacts between pyramidal neurons and bitufted interneurons in layer 2/3 of rat neocortex is enhanced by backpropagating action potentials
- pmid
- 14960603
- title
- Postsynaptic calcium influx at single synaptic contacts between pyramidal neurons and bitufted interneurons in layer 2/3 of rat neocortex is enhanced by backpropagating action potentials.
- contact Name
- Katharina Kaiser
- contributed by
- MPG
- checked by
- SR
- further action
consistent - Huguenard, JR - Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- Synaptic properties of callosal connections between L5PCs. AMPA conductances reported are ballpark consistent with what we prescribe.
- id
- 21
- species
- rat
- age
- p15-p21
- brain region
- pfC
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Callosal synaptic transmission
- key result(s)
- Paired stimuli used to assay presynaptic release properties showed
paired-pulse depression (PPD) in animals
- pmid
- 11731554
- title
- Properties of excitatory synaptic connections mediated by the corpus callosum in the developing rat neocortex.
- contact Name
- Huguenard, JR
- contributed by
- SR
- checked by
- SR
- further action
consistent - Hestrin, S - Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons.
- input/validation/consistent
- consistent
- evaluation criterion
- GABAa receptor kinetics. IPSC conductance, rise and decay times.
- id
- 22
- species
- rat
- age
- p13-p18
- brain region
- V1
- layer
- 5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- IPSC properties
- key result(s)
- Studies of the possible role of receptor desensitization in shaping the decay of the IPSCs
- pmid
- 9295368
- title
- Properties of GABAA receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
consistent - Sherman SM - Properties of the thalamic projection from the posterior medial nucleus to primary and secondary somatosensory cortices in the mouse.
- input/validation/consistent
- consistent
- evaluation criterion
- synaptic kinetics and dynamics of thalamic innervation
- id
- 23
- species
- mouse
- age
- p9-20
- brain region
- S1 S2
- layer
- 2/3 and 4
- presynaptic cell
- POm
- postsynaptic cell
- aspect
- synaptic properties
- key result(s)
- We studied the synaptic properties and anatomical features in the mouse of the projection from POm to all layers of S1 and to layer 4 of secondary somatosensory cortex (S2). Neurons in S1 responded to stimulation of POm with what has been termed Class 2 properties (paired-pulse facilitation, small initial excitatory postsynaptic potentials (EPSPs), a graded activation profile, and a metabotropic receptor component; thought to be modulatory), whereas neurons in layer 4 of S2 responded with Class 1A properties (paired-pulse depression, large initial EPSPs, an all-or-none activation profile, and no metabotropic receptor component, thought to be a main information input)
- pmid
- 22025694
- title
- Properties of the thalamic projection from the posterior medial nucleus to primary and secondary somatosensory cortices in the mouse.
- contact Name
- Sherman SM
- contributed by
- J-P
- checked by
- SR
- further action
consistent - Y. Zilberter - Pyramidal cell communication within local networks in layer 2/3 of rat neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- EPSP kinetic properties in L2/3 connections
- id
- 24
- species
- rat
- age
- p14-p16
- brain region
- visual- and somatosensory
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- PC,IN
- aspect
- EPSP and IPSP properties
- key result(s)
- EPSP amplitudes in the 0.2–1.0 mV range, EPSPs in pyramidal-pyramidal cell pairs did not detectably alter cell firing , In pyramidal-FS cell pairs, both unitary EPSPs and IPSPs efficiently modulated cell firing patterns
- pmid
- 12813147
- title
- Pyramidal cell communication within local networks in layer 2/3 of rat neocortex.
- contact Name
- Y. Zilberter
- contributed by
- MR
- checked by
- SR
- further action
consistent - Mieko Morishima - Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- mean no. of synapses/connection, unitary EPSC amplitudes and onset latency of L5PC connections in pFC are ballpark similar
- id
- 25
- species
- rat
- age
- p19
- brain region
- frontal
- layer
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- selective connectivity
- key result(s)
- The dendritic morphologies of CCS cells were correlated with their somatic depth within the cortex. CCS cells had reciprocal synaptic connections with each other and also provided synaptic input to CPn cells. However, connections from CPn to CCS cells were rarely found, even in pairs showing CCS to CPn connectivity. Additionally, CCS cells preferentially innervated the basal dendrites of other CCS cells but made contacts onto both the basal and apical dendrites of CPn cells.
- pmid
- 16624959
- title
- Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex.
- contact Name
- Mieko Morishima
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Thomson, Alex M - Relationships between morphology and physiology of pyramid-pyramid single axon connections in rat neocortex in vitro.
- input/validation/consistent
- consistent
- evaluation criterion
- EPSP kinetics of L5PCs
- id
- 26
- species
- rat
- age
- p21
- brain region
- S1
- layer
- 5 and 6
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- EPSP kinetics
- key result(s)
- Morphological basis for variations in functional properties of pyramid-pyramid connections in the neocortex
- pmid
- 7965856
- title
- Relationships between morphology and physiology of pyramid-pyramid single axon connections in rat neocortex in vitro.
- contact Name
- Thomson, Alex M
- contributed by
- Melissa
- checked by
- SR
- further action
consistent - Turrigiano, G - Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation.
- input/validation/consistent
- consistent
- evaluation criterion
- reported transmission failures and CV of EPSP amplitude are consistent with predictions in the reconstructed microcircuit
- id
- 27
- species
- rat
- age
- p14-17
- brain region
- V1
- layer
- L4
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- EPSC amplitude
- key result(s)
- Dynamic adjustment of the excitation-inhibition balance may allow the networks within layer 4 to maintain stable levels of activity in the face of variable sensory input
- pmid
- 15543139
- title
- Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation.
- contact Name
- Turrigiano, G
- contributed by
- SR
- checked by
- SR
- further action
consistent - Connors, BW - Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- Synaptic dynamics of SOM+ve -> PC & PC -> SOM+ve connections
- id
- 28
- species
- mouse
- age
- p13-p18
- brain region
- S1
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- Activation of SOM+ interneurons
- key result(s)
- Supragranular GFP expressing interneurons (GIN) form an electrically coupled network that exerts a coherent 3- to 10-Hz inhibitory influence on its targets. Because GIN cells are more readily activated than RS and FS cells, it is possible that they act as “first responders” when cortical excitatory activity increases.
- pmid
- 18799598
- title
- Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
- contact Name
- Connors, BW
- contributed by
- SR
- checked by
- SR
- further action
consistent - C.C.H. Petersen - Short-term dynamics of synaptic transmission within the excitatory neuronal network of rat layer 4 barrel cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- the USE and D values reported are consistent with the prescribed values for E2 pathways in the reconstructed microcircuit
- id
- 29
- species
- rat
- age
- p13-p15
- brain region
- barrel cortex
- layer
- L4
- presynaptic cell
- SP/SS
- postsynaptic cell
- SP/SS
- aspect
- short-term plasticity in vivo
- key result(s)
- Action potentials in presynaptic neurons at frequencies ranging from 1 to 100 Hz evoked depressing postsynaptic excitatory postsynaptic potentials (EPSPs). Recovery from synaptic depression followed an exponential time course with best-fit parameters that differed greatly between individual synaptic connections. The average maximal short-term depression was close to 0.5 with a recovery time constant of around 500 ms.
- pmid
- 12037194
- title
- Short-term dynamics of synaptic transmission within the excitatory neuronal network of rat layer 4 barrel cortex.
- contact Name
- C.C.H. Petersen
- contributed by
- MR
- checked by
- SR
- further action
consistent - Sceniak MP - Slow GABA(A) mediated synaptic transmission in rat visual cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- Slow GABAa kinetics from L2/3
- id
- 30
- species
- rat
- age
- p16-p28
- brain region
- visual cortex
- layer
- 2,3
- presynaptic cell
- 2,3
- postsynaptic cell
- PC,IN
- aspect
- slow GABAA receptor mediated inhibitory postsynaptic currents in neocortex
- key result(s)
- GABAA slow IPSCs displayed durations that were approximately 4 fold longer than typical GABAA fast IPSCs, but shorter than GABAB-mediated inhibition
- pmid
- 18199338
- title
- Slow GABA(A) mediated synaptic transmission in rat visual cortex.
- contact Name
- Sceniak MP
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Stephen R. Williams - Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- IPSP amplitudes between L1 interneurons
- id
- 31
- species
- rat
- age
- p24- 36
- brain region
- neocortex
- layer
- layer 1
- presynaptic cell
- interneurons
- postsynaptic cell
- PC
- aspect
- investigate the electrophysiological properties of layer 1 (L1) neurons of the rat somatosensory neocortex (postnatal day 24-36) and their synaptic connectivity with supragranular pyramidal neurons
- key result(s)
- a high specificity of excitatory and inhibitory connections in the superficial layers of the neocortex.
- pmid
- 21220765
- title
- Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex.
- contact Name
- Stephen R. Williams
- contributed by
- Mirjia Herzog
- checked by
- SR
- further action
consistent - Hestrin, S - Spike transmission and synchrony detection in networks of GABAergic interneurons.
- input/validation/consistent
- consistent
- evaluation criterion
- EPSC kinetics from L2/3 PCs to L2/3 FS cells
- id
- 32
- species
- rat
- age
- p15-p19
- brain region
- S1/V1
- layer
- 5
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- Spike Transmission and Synchrony Detection
- key result(s)
- networks of fast-spiking cells may play a role in the detection and promotion of synchronous activity within the neocortex
- pmid
- 11423653
- title
- Spike transmission and synchrony detection in networks of GABAergic interneurons.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
consistent - Daniel E. Feldman - Synapse-specific expression of functional presynaptic NMDA receptors in rat somatosensory cortex.
- input/validation/consistent
- consistent
- evaluation criterion
- The reconstruction does not include a model of presynaptic NMDARs. However, the reconstructed microcircuit is ballpark consistent with the peak AMPA EPSC values reported in this paper
- id
- 33
- species
- rat
- age
- P14-P22
- brain region
- Somatosensory Cortex
- layer
- 2/3 and 4
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Presynaptic NMDARs selectively modulate L4-L2/3 synapses, relative to other synapses made by the same neurons.
- key result(s)
- Existence of these receptors may support specialized processing or plasticity by L4-L2/3 synapses.
- pmid
- 18305253
- title
- Synapse-specific expression of functional presynaptic NMDA receptors in rat somatosensory cortex.
- contact Name
- Daniel E. Feldman
- contributed by
- John Fielden
- checked by
- SR
- further action
consistent - Patrik Krieger - Synaptic connections between layer 5B pyramidal neurons in mouse somatosensory cortex are independent of apical dendrite bundling.
- input/validation/consistent
- consistent
- evaluation criterion
- connection probability and EPSP amplitude between L5TTPCs are ballpark similar
- id
- 34
- species
- mouse
- age
- P14-P37
- brain region
- Barrel cortex
- layer
- Layer 5B
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- Connectivity between L5PCs
- key result(s)
- We found that apical dendrite bundles in the transgenic mice were anatom- ically similar to apical dendrite bundles previously proposed to be part of minicolumns. Pyramids within the same cluster had larger common dendritic domains compared with pyramids in adjacent clusters but did not receive more correlated synaptic inputs. L5B pyramids within and between clusters have similar connection probabilities and unitary EPSP amplitudes. Furthermore, intrinsically bursting and regular spiking pyramidal cells were both present within the same cluster. In conclusion, intrinsic electrical excitability and the properties of synaptic connections between this subtype of L5B pyramidal cells are independent of the cell clusters defined by bundling of their apical dendrites.
- pmid
- 17959790
- title
- Synaptic connections between layer 5B pyramidal neurons in mouse somatosensory cortex are independent of apical dendrite bundling.
- contact Name
- Patrik Krieger
- contributed by
- J. Ryge
- checked by
- SR
- further action
consistent - Hestrin, S - Synaptic interactions of late-spiking neocortical neurons in layer 1.
- input/validation/consistent
- consistent
- evaluation criterion
- IPSP amplitudes from L1 neurons
- id
- 35
- species
- rat
- age
- p14-p24
- brain region
- S1
- layer
- 1, 2,3
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- Electrical and chemical synaptic transmission
- key result(s)
- a group of GABAergic neurons within layer 1 are specifically interconnected by electrical coupling and can provide significant inhibitory inputs to neurons in layer 1 and to distal dendrites of pyramidal cells
- pmid
- 12514205
- title
- Synaptic interactions of late-spiking neocortical neurons in layer 1.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
consistent - Sherman SM - Synaptic properties of thalamic input to layers 2/3 and 4 of primary somatosensory and auditory cortices.
- input/validation/consistent
- consistent
- evaluation criterion
- Consistent with ballpark numbers for thalamocortical synapses
- id
- 36
- species
- mouse
- age
- p10-p18
- brain region
- S1, A1
- layer
- 2/3 and 4
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Thalamocortical innervation
- key result(s)
- thalamus is likely to be more than just a simple relay of information and may be directly modulating cortex.
- pmid
- 21047937
- title
- Synaptic properties of thalamic input to layers 2/3 and 4 of primary somatosensory and auditory cortices.
- contact Name
- Sherman SM
- contributed by
- Mirjia Herzog
- checked by
- SR
- further action
consistent - Stratford, K - Synaptic transmission between individual pyramidal neurons of the rat visual cortex in vitro.
- input/validation/consistent
- consistent
- evaluation criterion
- the predicted synaptic physiology of L2/3PCs in the reconstructed microcircuit is consistent with numbers mentioned in this paper
- id
- 37
- species
- rat
- age
- P14-16
- brain region
- visual
- layer
- 2,3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- synaptic transmission properties
- key result(s)
- All PSPs were depolarizing at rest (-74 +/- 5 mV, mean +/- SD), and all 14 of the PSPs that were also recorded with the postsynaptic cell depolarized to around action potential threshold (about -55 mV) remained depolarizing. PSPs had short latencies (1.2 +/- 0.6 msec, mean +/- SD), suggesting that they were mediated by monosynaptic pathways. Peak amplitudes of the averaged PSPs varied widely (range, 0.05-2.08 mV), but the majority were less than 0.5 mV
- pmid
- 1846012
- title
- Synaptic transmission between individual pyramidal neurons of the rat visual cortex in vitro.
- contact Name
- Stratford, K
- contributed by
- Kay
- checked by
- SR
- further action
consistent - Miesenbock, G - The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
- input/validation/consistent
- consistent
- evaluation criterion
- reported transmission failures for L2/3 to L2/3 connections are consistent with predictions in the reconstructed microcircuit
- id
- 38
- species
- mouse
- age
- adult
- brain region
- S1,V1,M1
- layer
- 2/3, 4, 5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- transmission failures
- key result(s)
- The failure values are higher than what we observe
- pmid
- 21076426
- title
- The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
- contact Name
- Miesenbock, G
- contributed by
- SR
- checked by
- SR
- further action
consistent - Connors, BW - Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortex.
- input/validation/consistent
- consistent
- evaluation criterion
- axonal conduction velocity estimates of ~0.4 m/s for L2/3 -> L5 PC connections
- id
- 39
- species
- rat
- age
- adult
- brain region
- S1
- layer
- 5
- presynaptic cell
- Exc. fibre afferents
- postsynaptic cell
- PC
- aspect
- synaptic properties
- key result(s)
- When electric stimuli were delivered within the same layer as the recorded cell, EPSPs could be evoked up to 2000 μm away for both layers 2/3 and 5 pyramids. Estimates of horizontal axonal conduction velocities (∼0.4 m/s) and the thresholds for activation also did not differ between layers.
- pmid
- 12759179
- title
- Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortex.
- contact Name
- Connors, BW
- contributed by
- SR
- checked by
- SR
- further action
inconsistent - Elodie Fino - Dense inhibitory connectivity in neocortex.
- input/validation/consistent
- inconsistent
- evaluation criterion
- The reported connection probability in the paper is higher than in the reconstructed microcircuit for BC -> * connections. The difference could arise from the fact that the paper gathers data from mouse neocortex.
- id
- 40
- species
- mouse
- age
- P11-41
- brain region
- frontal cortex
- layer
- 2,3
- presynaptic cell
- MC
- postsynaptic cell
- PC
- aspect
- Martinotti Cell Loop
- key result(s)
- All to all Martinotti cell - PC connectivity
- pmid
- 21435562
- title
- Dense inhibitory connectivity in neocortex.
- contact Name
- Elodie Fino
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
inconsistent - Elodie Fino - Dense inhibitory connectivity in neocortex.
- input/validation/consistent
- inconsistent
- evaluation criterion
- The reported connection probability in the paper is higher than in the reconstructed microcircuit for BC -> * connections. The difference could arise from the fact that the paper gathers data from mouse neocortex.
- id
- 41
- species
- mouse
- age
- P11-41
- brain region
- PfC
- layer
- 2,3
- presynaptic cell
- SOM+
- postsynaptic cell
- PC
- aspect
- SOM+ - PC connectivity
- key result(s)
- Connection probabilities and convergence of SOM+ cells onto PCs
- pmid
- 21435562
- title
- Dense inhibitory connectivity in neocortex.
- contact Name
- Elodie Fino
- contributed by
- SR
- checked by
- SR
- further action
inconsistent - Adam Packer - Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition?
- input/validation/consistent
- inconsistent
- evaluation criterion
- The reported connection probability in the paper is higher than in the reconstructed microcircuit for BC -> * connections. The difference could arise from the fact that the paper gathers data from mouse neocortex.
- id
- 42
- species
- mouse
- age
- P12-45
- brain region
- frontal cortex
- layer
- 2,3
- presynaptic cell
- PV+
- postsynaptic cell
- PC
- aspect
- PV+ cell connectivity
- key result(s)
- All to all PV+ cell - PC connectivity
- pmid
- 21917809
- title
- Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition?
- contact Name
- Adam Packer
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
inconsistent - Komatsu, Y - Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.
- input/validation/consistent
- inconsistent
- evaluation criterion
- reported EPSC values are lower than ballpark numbers
- id
- 43
- species
- mouse
- age
- p20-p30
- brain region
- S1
- layer
- L2/3 - L6
- presynaptic cell
- PC
- postsynaptic cell
- MC like
- aspect
- EPSC amplitude
- key result(s)
- The paper reports EPSC values between L2/3 PCs, which are much lower than the ballpark estimates
- pmid
- 17478724
- title
- Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons.
- contact Name
- Komatsu, Y
- contributed by
- SR
- checked by
- SR
- further action
inconsistent - Miesenbock, G - The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
- input/validation/consistent
- inconsistent
- evaluation criterion
- The predicted rise times for L4 to L4 connections in the reconstructed microcircuit are lower than reported values
- id
- 44
- species
- mouse
- age
- adult
- brain region
- S1,V1,M1
- layer
- 2/3, 4, 5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- IPSC rise times
- key result(s)
- The IPSC rise times reported are higher than previous estimates
- pmid
- 21076426
- title
- The columnar and laminar organization of inhibitory connections to neocortical excitatory cells
- contact Name
- Miesenbock, G
- contributed by
- SR
- checked by
- SR
- further action
input - Thomson, Alex M - Binomial parameters differ across neocortical layers and with different classes of connections in adult rat and cat neocortex.
- input/validation/consistent
- input
- evaluation criterion
- The paper provides estimates of number of release sites, release probability and quantal size for a few neocortical pathways
- id
- 45
- species
- rat
- age
- p14-p18
- brain region
- S1
- layer
- L2/3 - L6
- presynaptic cell
- PC
- postsynaptic cell
- BC, BTC, MC
- aspect
- EPSP mean, Quantal size, Probability of release, No. of release sites
- key result(s)
- Binomial model-based analysis compared excitatory connections involving different classes of neurons in different neocortical layers.
- pmid
- 17702864
- title
- Binomial parameters differ across neocortical layers and with different classes of connections in adult rat and cat neocortex.
- contact Name
- Thomson, Alex M
- contributed by
- SR
- checked by
- SR
- further action
input - Feldmeyer, D., Luebke, J., Sakmann, B. - Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats
- input/validation/consistent
- input
- evaluation criterion
- EPSP kinetic properties in homonymous L2/3PC synaptic connections
- id
- 46
- species
- rat
- age
- p17-p23
- brain region
- barrel cortex
- layer
- 2,3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- synaptic anatomy & physiology
- key result(s)
- latency of unitary EPSPs was 1.1 ± 0.4 ms, the 20–80% rise time was 0.7 ± 0.2 ms, the average amplitude was 1.0 ± 0.7 mV and the decay time constant was 15.7 ± 4.5 ms
- pmid
- 16793907
- title
- Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats
- contact Name
- Feldmeyer, D., Luebke, J., Sakmann, B.
- contributed by
- MR
- checked by
- SR
- further action
input - C. Stricker - Properties of mEPSCs recorded in layer II neurones of rat barrel cortex.
- input/validation/consistent
- input
- evaluation criterion
- mEPSC amplitudes and frequency
- id
- 47
- species
- rat
- age
- P12 - P17
- brain region
- somatosensory cortex
- layer
- L2
- presynaptic cell
- postsynaptic cell
- aspect
- Properties of mEPSCs
- key result(s)
- high frequency of spontaneous postsynaptic currents (on average 33 ± 13 Hz). The rise time of the fastest (10 %) mEPSCs was 288 ± 86 ms (10–90 %) and the halfwidth was 1073 ± 532 ms. The amplitude was _5.9 ± 1.1 pA with a coefficient of variation of 0.44 ± 0.14. The rate of mEPSCs was very temperature sensitive with a Q10 (33–37 C) of 8.9 ± 0.9.
- pmid
- 12456830
- title
- Properties of mEPSCs recorded in layer II neurones of rat barrel cortex.
- contact Name
- C. Stricker
- contributed by
- Oli
- checked by
- SR
- further action
input - Feldmeyer, D. - Synaptic connections between layer 4 spiny neurone- layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
- input/validation/consistent
- input
- evaluation criterion
- EPSP kinetic properties from L4SS to L2/3PCs
- id
- 48
- species
- rat
- age
- p17-p23
- brain region
- barrel cortex
- layer
- 2/3,4
- presynaptic cell
- SS
- postsynaptic cell
- PC
- aspect
- synaptic anatomy & physiology
- key result(s)
- number of putative contacts of 4.5 ± 0.5, average latency of 2.1 ± 0.6 ms, rise time of 0.8 ± 0.3 ms and decay time constant of 12.7 ± 3.5 ms
- pmid
- 11826166
- title
- Synaptic connections between layer 4 spiny neurone- layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
- contact Name
- Feldmeyer, D.
- contributed by
- MR
- checked by
- SR
- further action
not applicable - Armen Stepanyants - Cooperative synapse formation in the neocortex.
- input/validation/consistent
- not applicable
- evaluation criterion
- Theoretical study that partly uses anatomical data from Markram et al. 1997 for TTL5 connections
- id
- 49
- species
- rat
- age
- p12-p23 and p26-p36
- brain region
- barrel cortex
- layer
- 2 to 5
- presynaptic cell
- EC
- postsynaptic cell
- synaptic connectivity between EC / modeling and data
- aspect
- Theoretical study modelling synapse formation
- key result(s)
- a cooperative scheme of synapse formation where multiple-synapticconnections between neurons are stabilized while neurons that donot establish a critical number of synapses are not likely to remainsynaptically coupled
- pmid
- 19805321
- title
- Cooperative synapse formation in the neocortex.
- contact Name
- Armen Stepanyants
- contributed by
- MPG
- checked by
- SR
- further action
not applicable - Paolo Medini - Layer- and cell-type-specific subthreshold and suprathreshold effects of long-term monocular deprivation in rat visual cortex.
- input/validation/consistent
- not applicable
- evaluation criterion
- Ocular deprivation experiments in V1. NB: Contains some in vivo dendritic reconstructions of L23, L4 and L5 PCs
- id
- 50
- species
- rat
- age
- p21 -p30
- brain region
- V1
- layer
- 2 to 6
- presynaptic cell
- postsynaptic cell
- PC
- aspect
- In vivo, recordings and stainings of usage dependant plasticity in PC in V1
- key result(s)
- Layer- and Cell-Type-Specific Subthreshold andSuprathreshold Effects of Long-Term MonocularDeprivation in Rat Visual Cortex
- pmid
- 22114282
- title
- Layer- and cell-type-specific subthreshold and suprathreshold effects of long-term monocular deprivation in rat visual cortex.
- contact Name
- Paolo Medini
- contributed by
- MPG
- checked by
- SR
- further action
not applicable - Wouterlood, F. G - Morphological and numerical analysis of synaptic interactions between neurons in deep and superficial layers of the entorhinal cortex of the rat.
- input/validation/consistent
- not applicable
- evaluation criterion
- not applicable
- id
- 51
- species
- rat
- age
- adult
- brain region
- entorhinal cx
- layer
- L5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Axon terminals in L1-2 and 3: 95% of synapses asymmetrical, Of these, 56% occurred with spines and 44% with dendritic shafts. The other 5% of synapses were symmetrical and occurred mainly on dendritic shafts (only 2 cases on spines)
- key result(s)
- In the EC, deep to superficial projection is mainly excitatory in nature.These fibers subserve both excitation and feed-forward inhibition
- pmid
- 14750656
- title
- Morphological and numerical analysis of synaptic interactions between neurons in deep and superficial layers of the entorhinal cortex of the rat.
- contact Name
- Wouterlood, F. G
- contributed by
- Melissa
- checked by
- SR
- further action
not applicable - Song-Hai Shi - Specific synapses develop preferentially among sister excitatory neurons in the neocortex.
- input/validation/consistent
- not applicable
- evaluation criterion
- not applicable - developmental study of synaptogenesis
- id
- 52
- species
- mouse
- age
- E12-13
- brain region
- neocortex
- layer
- -
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Specific synapses
- key result(s)
- develop preferentially among sister excitatory neurons in the neocortex.
- pmid
- 19204731
- title
- Specific synapses develop preferentially among sister excitatory neurons in the neocortex.
- contact Name
- Song-Hai Shi
- contributed by
- Rajnish
- checked by
- SR
- further action
not applicable - Favero, M. - Spike timing plays a key role in synapse elimination at the neuromuscular junction.
- input/validation/consistent
- not applicable
- evaluation criterion
- Neuromuscular junction
- id
- 53
- species
- rat
- age
- P0-30
- brain region
- neuromuscular junction
- layer
- all
- presynaptic cell
- postsynaptic cell
- aspect
- neuromuscular junction
- key result(s)
- precise spike timing plays an instructive role in synaptic modification.
- pmid
- 22619332
- title
- Spike timing plays a key role in synapse elimination at the neuromuscular junction.
- contact Name
- Favero, M.
- contributed by
- John Fielden
- checked by
- SR
- further action
not implemented - Andreas Luethi - A disinhibitory microcircuit for associative fear learning in the auditory cortex.
- input/validation/consistent
- not implemented
- evaluation criterion
- Nicotinic modulation is currently not implemented in the reconstructed microcircuit
- id
- 54
- species
- mouse
- age
- 1.5 to 6 months
- brain region
- A1
- layer
- 1,2,3
- presynaptic cell
- L1
- postsynaptic cell
- L2/3 PV +ve interneuron
- aspect
- PV+ cell connectivity
- key result(s)
- we observed morphological and functional synaptic contacts between L1 interneurons and PV1 interneurons
- pmid
- 22158104
- title
- A disinhibitory microcircuit for associative fear learning in the auditory cortex.
- contact Name
- Andreas Luethi
- contributed by
- Shruti
- checked by
- SR
- further action
not implemented - Hestrin, S - Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex.
- input/validation/consistent
- not implemented
- evaluation criterion
- CB1 receptor kinetics are currently not implemented in the reconstructed microcircuit
- id
- 55
- species
- mouse
- age
- p14-p20
- brain region
- S1
- layer
- 2,3
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- Receptor sensitivity
- key result(s)
- activity-dependent release of cannabinoids, by blocking CB1-IS synapses, may alter the role of inhibition in neocortical circuits
- pmid
- 18203691
- title
- Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
not implemented - Feldmeyer, D. - Developmental alterations in the functional properties of excitatory neocortical synapses.
- input/validation/consistent
- not implemented
- evaluation criterion
- Developmental changes are currently not implemented
- id
- 56
- species
- rat, mouse
- age
- P14, P29
- brain region
- S1
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Synaptic properties
- key result(s)
- excitatory connections in neocortex and STDP mechanisms change with development. Older animals have less reliable excitatory synapses, lower release probability, mild facilitation in some cases.
- pmid
- 19273572
- title
- Developmental alterations in the functional properties of excitatory neocortical synapses.
- contact Name
- Feldmeyer, D.
- contributed by
- Rodrigo
- checked by
- SR
- further action
not implemented - Hestrin, S - Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
- input/validation/consistent
- not implemented
- evaluation criterion
- CB1 receptor kinetics are currently not implemented in the reconstructed microcircuit
- id
- 57
- species
- mouse
- age
- p14-p20
- brain region
- S1
- layer
- 2,3
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- Electrical coupling
- key result(s)
- A population of electrically coupled CB1-IS GABAergic interneurons in the neocortex that share a unique morphology and a characteristic pattern of irregular spiking in response to current injection
- pmid
- 15525762
- title
- Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
not implemented - Wang Yun - Electrotonic coupling between pyramidal neurons in the neocortex.
- input/validation/consistent
- not implemented
- evaluation criterion
- Gap junctions are currently not implemented in the reconstructed microcircuit
- id
- 58
- species
- rat
- age
- P14-P43
- brain region
- medial PFC
- layer
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- gap junctions
- key result(s)
- Existing of gap junctions between PCs
- pmid
- 20436674
- title
- Electrotonic coupling between pyramidal neurons in the neocortex.
- contact Name
- Wang Yun
- contributed by
- Werner
- checked by
- SR
- further action
not implemented - Gabor Tamas - Gap-junctional coupling between neurogliaform cells and various interneuron types in the neocortex.
- input/validation/consistent
- not implemented
- evaluation criterion
- Gap junctions are currently not implemented in the reconstructed microcircuit
- id
- 59
- species
- rat
- age
- P20-35
- brain region
- S1
- layer
- L2/3
- presynaptic cell
- NGC
- postsynaptic cell
- NGC, PC
- aspect
- gap junctions between NFGCs and other interneurons
- key result(s)
- Apart from eliciting combined GABAA and GABAB receptor-mediated inhibition on pyramidal cells, neurogliaform cells establish electrical synapses and link multiple networks formed by gap junctions restricted to a particular class of interneuron.
- pmid
- 16000617
- title
- Gap-junctional coupling between neurogliaform cells and various interneuron types in the neocortex.
- contact Name
- Gabor Tamas
- contributed by
- Shruti
- checked by
- SR
- further action
not implemented - Yasuo Kawaguchi - Highly differentiated projection-specific cortical subnetworks.
- input/validation/consistent
- not implemented
- evaluation criterion
- Extracortical projections through crossed corticostriatal (CCS) cells projecting to the contralateral striatum (cortico-basal ganglia pathway) and corticopontine (CPn) cells that project to the pons (cortico-cerebellar pathway)
- id
- 60
- species
- rat
- age
- P17-23
- brain region
- neocortex
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- subnetworks
- key result(s)
- Intracortical circuits of pyramidal neurons reflect their long-range axonal targets
- pmid
- 21753015
- title
- Highly differentiated projection-specific cortical subnetworks.
- contact Name
- Yasuo Kawaguchi
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
not implemented - Hestrin, S - Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
- input/validation/consistent
- not implemented
- evaluation criterion
- We lack reconstructions of long range axons for the moment
- id
- 61
- species
- mouse
- age
- p14-p17
- brain region
- pfC
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- long range connectivity
- key result(s)
- The frequency of monosynaptic connections among corticostriatal pyramidal neurons is significantly higher than among corticocortical or corticotectal pyramidal neurons. The probability of feed-forward connections from corticocortical neurons to corticotectal neurons is approximately three- to fourfold higher than the probability of monosynaptic connections among corticocortical or corticotectal cells.
- pmid
- 19151698
- title
- Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
not implemented - Shaul Hestrin - Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
- input/validation/consistent
- not implemented
- evaluation criterion
- Reconstructions of long range axons are currently lacking
- id
- 62
- species
- mouse
- age
- P14-17
- brain region
- neocortex
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- subnetworks
- key result(s)
- Intracortical circuits of pyramidal neurons reflect their long-range axonal targets
- pmid
- 19151698
- title
- Intracortical circuits of pyramidal neurons reflect their long-range axonal targets.
- contact Name
- Shaul Hestrin
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
not implemented - Song-Hai Shi - Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly.
- input/validation/consistent
- not implemented
- evaluation criterion
- Gap junctions are not implemented for the moment
- id
- 63
- species
- mouse
- age
- E12–E13, P1–28
- brain region
- neocortex
- layer
- all
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Gap junction bias
- key result(s)
- Gap junctions develop preferentially among sister excitatory neurons in the neocortex. And lead to the appearance of synaptic connections.
- pmid
- 22678291
- title
- Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly.
- contact Name
- Song-Hai Shi
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
possibly consistent - Burkhalter, A - Distinct GABAergic targets of feedforward and feedback connections between lower and higher areas of rat visual cortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 64
- species
- mouse
- age
- mouse
- brain region
- mouse
- layer
- 1,2/3
- presynaptic cell
- SOM+, PV+, CR+ neurons
- postsynaptic cell
- SOM+, PV+, CR+ neurons
- aspect
- GABAergic targets of of feedforward and feedback Connections Between Lower and Higher Areas of Rat Visual Cortex
- key result(s)
- Feedforward (FF) and feedback (FB) influences on L2/3 PCs mainly involve disynaptic connections via PV+ neurons that control the spike outputs to axons and proximal dendrites. Unlike FF input, FB input in addition makes a disynaptic link via CR+ neurons, which may influence the excitability of distal pyramidal cell dendrites in layer 1.
- pmid
- 14645486
- title
- Distinct GABAergic targets of feedforward and feedback connections between lower and higher areas of rat visual cortex.
- contact Name
- Burkhalter, A
- contributed by
- SR
- checked by
- SR
- further action
possibly consistent - Hestrin, S - Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 65
- species
- mouse
- age
- adult
- brain region
- S1
- layer
- 2/3,4,5
- presynaptic cell
- BC
- postsynaptic cell
- BC
- aspect
- GABAergic transmission
- key result(s)
- PV-FS cells connected in the adult cerebral cortex by both electrical and chemical synapses, establishing networks that can have important implications for coordinating activity in cortical circuits.
- pmid
- 12213962
- title
- Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
possibly consistent - Takeshi Otsuka and Yasuo Kawaguchi - Firing-pattern-dependent specificity of cortical excitatory feed-forward subnetworks.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- Connectivity motifs from L2/3 to L5 PCs. Also EPSC kinetics from L2/3 to L5 PCs
- id
- 66
- species
- rat
- age
- P20-29
- brain region
- neocortex
- layer
- 2,5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Clustering of connections
- key result(s)
- excitatory subnetworks are correlated with electrical firing types
- pmid
- 18971461
- title
- Firing-pattern-dependent specificity of cortical excitatory feed-forward subnetworks.
- contact Name
- Takeshi Otsuka and Yasuo Kawaguchi
- contributed by
- Rodrigo
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
possibly consistent - Yasuo Kawaguchi - Highly differentiated projection-specific cortical subnetworks.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation - connection probability of L5TTPC (a.k.a corticopontine cells by few groups) & L5STPC (a.k.a corticocallosal by few groups) cells
- id
- 67
- species
- rat
- age
- p19-p23
- brain region
- frontal cortex
- layer
- L5
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- thalamocortical projections
- key result(s)
- Highly Differentiated Projection-Specific Cortical Subnetworks
- pmid
- 21753015
- title
- Highly differentiated projection-specific cortical subnetworks.
- contact Name
- Yasuo Kawaguchi
- contributed by
- MPG
- checked by
- SR
- further action
possibly consistent - Dmitri Chklovskii - Highly nonrandom features of synaptic connectivity in local cortical circuits.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 68
- species
- rat
- age
- P12-20
- brain region
- visual cx
- layer
- 5
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- PC-PC connectivity
- key result(s)
- Triplet connectivity
- pmid
- 15737062
- title
- Highly nonrandom features of synaptic connectivity in local cortical circuits.
- contact Name
- Dmitri Chklovskii
- contributed by
- Rodrigo Perin
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
possibly consistent - Callaway, E - Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 69
- species
- rat
- age
- p25-p30
- brain region
- S1
- layer
- 6
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- sources of laminar input
- key result(s)
- provides insight into differences in function between cortical projections to first-order versus higher-order thalamic nuclei and also show that these circuits can be organized differently in different species
- pmid
- 10862703
- title
- Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons.
- contact Name
- Callaway, E
- contributed by
- SR
- checked by
- SR
- further action
possibly consistent - Massimo Scanziani - Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 70
- species
- rat
- age
- P14-27
- brain region
- somatosensory cortex
- layer
- Layer 2/3
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- Disynaptic inhibition
- key result(s)
- Neocortical inhibition is recruited by classical somatodendritic integration rather than direct activation of interneuron axon terminals.
- pmid
- 19605636
- title
- Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
- contact Name
- Massimo Scanziani
- contributed by
- Rajnish
- checked by
- SR
- further action
- Analysis iterations. Estimated time: 3-4 days
possibly consistent - Contreras, D - Nonlinear integration of sensory responses in the rat barrel cortex: an intracellular study in vivo.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evlaution
- id
- 71
- species
- rat
- age
- adult
- brain region
- S1
- layer
- 2 to 6
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- synaptic integration of sensory inputs
- key result(s)
- To study integration of converging sensory inputs on single cortical neurons, the authors performed intracellular recordings in vivo in the barrel cortex of the barbiturate-anesthetized rat
- pmid
- 14614077
- title
- Nonlinear integration of sensory responses in the rat barrel cortex: an intracellular study in vivo.
- contact Name
- Contreras, D
- contributed by
- SR
- checked by
- SR
- further action
possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 72
- species
- rat
- age
- rat
- brain region
- rat
- layer
- 2,3
- presynaptic cell
- interneurons and pyramidal cells
- postsynaptic cell
- interneurons and pyramidal cells
- aspect
- P/Q-type VGCC
- key result(s)
- direct pharmacological evidence that P/Q-type but not N-Type VGCC mediate GABA release from presynaptic terminals at inhibitory synapses from parvalbumin-positive fast spiking interneurons to pyramidal cells in the rat neocortex.
- pmid
- 17329622
- title
- P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
- contact Name
- Zaitsev A V
- contributed by
- Monica Favre
- checked by
- SR
- further action
possibly consistent - Y. Zilberter - Pyramidal cell communication within local networks in layer 2/3 of rat neocortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation - connection probability of L23/PCs and BCs as a function of distance
- id
- 73
- species
- rat
- age
- p14-p16
- brain region
- visual- and somatosensory
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- cortico-cortical projections / P
- key result(s)
- Input map into L2/3 PCs. Distance dependent conenction propability. "an individual pyramidal cell receives synaptic inputs from about 30 other pyramidal neurons; The probability of connection decreased from 0.09 to 0.01 with intercell distance (over the range 25–200 μm); excitatory and inhibitory connections between pyramidal cells and FS interneurons decreased only slightly with distance, being in the range 0.5–0.75"
- pmid
- 12813147
- title
- Pyramidal cell communication within local networks in layer 2/3 of rat neocortex.
- contact Name
- Y. Zilberter
- contributed by
- MR
- checked by
- SR
- further action
possibly consistent - Contreras, D - Synaptic responses to whisker deflections in rat barrel cortex as a function of cortical layer and stimulus intensity.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evlaution
- id
- 74
- species
- rat
- age
- adult
- brain region
- S1
- layer
- 2 to 6
- presynaptic cell
- PC
- postsynaptic cell
- PC
- aspect
- synaptic integration of sensory inputs
- key result(s)
- In all cells, depolarization reduced the duration and amplitude of the response, but only in Gr cells did it reveal an early IPSP that cut short the EPSP. This early IPSP was associated with a large decrease in input resistance and an apparent reversal potential below spike threshold
- pmid
- 15102914
- title
- Synaptic responses to whisker deflections in rat barrel cortex as a function of cortical layer and stimulus intensity.
- contact Name
- Contreras, D
- contributed by
- SR
- checked by
- SR
- further action
possibly consistent - Hestrin, S - Synaptogenesis of electrical and GABAergic synapses of fast-spiking inhibitory neurons in the neocortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 75
- species
- mouse
- age
- p3-p18
- brain region
- S1
- layer
- 5,6
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- Development of GABAergic transmission
- key result(s)
- Chemical and electrical connections among FS interneurons can contribute to patterned neocortical activity only by the end of the first postnatal week
- pmid
- 21795529
- title
- Synaptogenesis of electrical and GABAergic synapses of fast-spiking inhibitory neurons in the neocortex.
- contact Name
- Hestrin, S
- contributed by
- SR
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
possibly consistent - Levelt, C - Synaptotagmin-2 is a reliable marker for parvalbumin positive inhibitory boutons in the mouse visual cortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 76
- species
- mouse
- age
- mouse
- brain region
- mouse
- layer
- 4,6
- presynaptic cell
- IN, PC
- postsynaptic cell
- IN, PC
- aspect
- synaptic proteins
- key result(s)
- In adult V1 synaptotagmin (Syt2) is only found in inhibitory, VGAT positive boutons. Practically all Syt2 positive boutons also contain PV and vice versa.
- pmid
- 22539967
- title
- Synaptotagmin-2 is a reliable marker for parvalbumin positive inhibitory boutons in the mouse visual cortex.
- contact Name
- Levelt, C
- contributed by
- SR
- checked by
- SR
- further action
possibly consistent - Keller, A - The patterns and synaptic properties of horizontal intracortical connections in the rat motor cortex.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 77
- species
- rat
- age
- p12-p17
- brain region
- motor cortex
- layer
- 2,3,5
- presynaptic cell
- 2,3,5
- postsynaptic cell
- PC
- aspect
- patterns and synaptic properties of horizontal intracortical connections
- key result(s)
- horizontal axons in layer II/III provide strong monosynaptic input to dendrites of layer II and III pyramidal cells in a distant column, and weaker monosynaptic input to layer V and VI cells by synapsing on dendritic fields at the border of layer III and V and in deep layer V. When these pathways are activated, layer II/III cells may relay excitatory activity to upper and deep layer V, as well as to other cells in layer II/III of the same column. Axons arising from layer V provide monosynaptic input to pyramidal cells in all layers of neighboring columns, by synapsing in two dendritic fields: one in the superficial layers and the other in middle layer V. Activation of these pathways may generate a disynaptic intracolumnar input from layer II/III cells to middle layer V, as well as to other cells in layer II/III.
- pmid
- 7904301
- title
- The patterns and synaptic properties of horizontal intracortical connections in the rat motor cortex.
- contact Name
- Keller, A
- contributed by
- Kay
- checked by
- SR
- further action
possibly consistent - Debora Ledergerber - The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation
- id
- 78
- species
- rat
- age
- p28 - p49
- brain region
- somatosensory cortex
- layer
- L2/3, L5 & L6
- presynaptic cell
- postsynaptic cell
- PC
- aspect
- short-term plasticity time window in dendrites
- key result(s)
- The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex
- pmid
- 22427971
- title
- The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex
- contact Name
- Debora Ledergerber
- contributed by
- MPG
- checked by
- SR
- further action
- Simulation-analysis iterations. Estimated time: 4-5 days
possibly consistent - Masanori Matsuzaki - Three-Dimensional Mapping of Unitary Synaptic Connections by Two-Photon Macro Photolysis of Caged Glutamate
- input/validation/consistent
- possibly consistent
- evaluation criterion
- pending evaluation - connection probability as a function of distance of L2/3PCs and L4PCs
- id
- 79
- species
- rat
- age
- p15-p19
- brain region
- visual cortex
- layer
- L2/3
- presynaptic cell
- PC
- postsynaptic cell
- aspect
- cortico-cortical projections
- key result(s)
- high resolution map of inputs L4->L2/3, L2/3->L2/3; profile of distance dependent connection strength (EPSC)
- pmid
- 18216227
- title
- Three-Dimensional Mapping of Unitary Synaptic Connections by Two-Photon Macro Photolysis of Caged Glutamate
- contact Name
- Masanori Matsuzaki
- contributed by
- MR
- checked by
- SR
- further action
possibly consistent - Stephen R. Williams - Voltage- and site-dependent control of the somatic impact of dendritic IPSPs.
- input/validation/consistent
- possibly consistent
- evaluation criterion
- distance dependent IPSP attenuation in L5TTPCs
- id
- 80
- species
- rat
- age
- P28-P42
- brain region
- S1
- layer
- 5
- presynaptic cell
- IN
- postsynaptic cell
- PC
- aspect
- IPSP attenuation
- key result(s)
- somatic impact of dendritic IPSPs is highly voltage dependent
- pmid
- 12917370
- title
- Voltage- and site-dependent control of the somatic impact of dendritic IPSPs.
- contact Name
- Stephen R. Williams
- contributed by
- Werner
- checked by
- SR
- further action